Dr. Carla Oliveira from Ipatimup – Institute of Molecular Pathology and Immunology of the University of Porto, Portugal will be the lecturer during this webinar. She will focus on known germline genetic causes, cancer risk estimates, surveillance and prevention of gastric cancer related tumour risk syndromes.
Hereditary gastric cancer accounts for 1-3% of the global burden of gastric cancer and comprises two major genetically explained syndromes: Hereditary Diffuse Gastric Cancer (HDGC) and Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS). Additionally Familial Intestinal Gastric Cancer, also believed to be genetically determined remains unresolved. The risk of gastric cancer development is high in HDGC families, mainly if these are carriers of germline causing variants in CDH1 (E-cadherin) and CTNNA1 (alpha-E-catenin) genes; and in GAPPS families mainly if these carry germline causing variants in the APC promoter 1B. The current knowledge on the genetics, pathogenesis and clinical aspects of hereditary gastric cancer syndromes will be presented in this webinar.