Lynch and polyposis

Endorsed* guidelines for Lynch and polyposis, and hereditary CRC

* ERN GENTURIS uses AGREE II as a tool for the endorsement of guidelines. The quality of the guideline is evaluated through assessing the rigor and transparency of the guideline development process. The content of the guideline is not evaluated, although selection of the guideline for endorsement includes expert opinion on the usefulness of the content of the guideline.

Lynch syndrome:

  • The Manchester International Consensus Group recommendations for the management of gynecological cancers in Lynch syndrome

    Authors: Emma J. Crosbie et al.

    Genet Med. 2019 Oct;21(10):2390-2400.

    Endorsed in September 2021


  • Endoscopic management of Lynch syndrome and of familial risk of colorectal cancer: European Society of Gastrointestinal Endoscopy (ESGE) Guideline

    Authors: Leerdam et al.

    Endoscopy 2019 51: 1082–1093.

    Endorsed in June 2021


  • European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender

    Authors: Seppälä et al.

    British Journal of Surgery 2020.

    Endorsed in June 2021

Polyposis syndromes:

  • Endoscopic management of polyposis syndromes: European Society of Gastrointestinal Endoscopy (ESGE) Guideline

    Authors: Monique E van Leerdam et al.

    Endoscopy. 2019 Sep;51(9):877-895.

    Endorsed in September 2021


  • The Management of Peutz-Jeghers Syndrome: European Hereditary Tumour Group (EHTG) Guideline

    Authors: Anja Wagner et al.

    J Clin Med. 2021 Jan 27;10(3):473.

    Endorsed in September 2021

Hereditary colorectal cancer:

  • Guidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and Ireland (ACPGBI)/United Kingdom Cancer Genetics Group (UKCGG)

    Authors: Monahan et al.

    Gut 2020;69:411–444.

    Endorsed in June 2021